Forecasters have predicted parts of the state could see its heaviest rain in years, with potential rainfall totals between 100mm to 150mm or even "even isolated totals of 200mm per day".
The rain will bear down across a broad area from Saturday and continue through to the middle of next week.
It will move through a wide area including North Mackay, inland parts of the state, and around Mount Isa.
However Bureau of Meteorology senior meteorologist Harry Clark said not every town will receive heavy rainfall each day.
"There's absolutely a heavy rainfall risk for much of northern Queensland for Saturday and Sunday," Clark said.
"The heavy rainfall will be in relatively localised pockets but certainly broad across that region."
Clark said it's not unusual for this part of the country to receive this much rain but what is different is "the prolonged nature of the event".
The wet weather is then expected to move north towards the end of next week.
There will be a risk of flash flooding due to the heavy rain.
This type of flooding happens in a short duration with relatively high flow occurring within six hours of rain falling.
The advice is not to drive through floodwaters, follow the advice of the emergency services and stay up to date with the latest weather information for your area.
Riverine flooding is also a risk and a broad warning is currently in place stretching from the Daintree and north of Mackay to the Gulf.
When there is a warning for this form of flooding, creeks and rivers can rise and even break their banks.
Across Australia, lows and troughs will also generate showers, rain and storms over Western Australia's Kimberley region, the Northern Territory and New South Wales.
The weather system will draw heat into South Australia, Victoria, New South Wales and southern Queensland.
Onshore winds are expected to drive several showers along the eastern seaboard and far southwestern Western Australia.
According to Weatherzone, at least four cities will experience soaring temperatures in the coming days.
Adelaide can expect a 38C day on Saturday, while Melbourne could reach as high as 37C.
Sydney's outer western suburbs can expect the heat to climb to 35C by Sunday.
Hobart is predicted to hit a top of 31C on Saturday, which is expected to be the capital city's first 30-degree day of the year.
The humidity could make some places feel hotter and potentially trigger widespread thunderstorms in several areas.