Notably, residents who test positive to COVID-19 will be able to leave their seven day isolation period under select conditions.
"Positive cases must still isolate for seven days from the day they took their test but may now leave home to drive a household member directly to or from education or work without leaving their vehicle," a statement from the Victorian Government said.
"They can also leave home to get medical care, a COVID-19 test, or in an emergency, including the risk of harm."
Additionally, Victorians will no longer have to wear masks in airports – although face coverings remain mandatory on flights, and other forms of public transport.
It comes days after the Australian Health Protection Principal Committee proposed the mandate be removed.
The state's essential worker vaccine mandate will also be eased for a number of industries – with the exception of healthcare workers who work with the vulnerable.
"To continue to protect the most vulnerable through winter, workers who interact with a vulnerable person will still require three COVID-19 vaccine doses. This includes residential aged care and disability care, healthcare, and custodial and emergency services, including police.
"Government imposed third dose mandates in education, food distribution, meat and seafood processing and quarantine accommodation sectors will be lifted.
"In line with other jurisdictions around Australia, vaccination policies will be the responsibility of individual workplaces."
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Aged care and disability care facilities will no longer have visitor caps.
"Residents (are) able to see any number of people as long as they test negative on a rapid antigen test that day," a statement says.
It comes after the state today recorded 6601 new cases, and 29 deaths.
Minister for Health Martin Foley said the changes allows "Victorians to live safely with COVID-19".
"Modest changes to our public health measures will keep Victorians protected as we continue to safely lift mandates and support businesses and individuals to begin to manage their own COVID-19 risk," he said.